Demonstration of formaldehyde dehydrogenase activity in formaldehyde-resistant Enterobacteriaceae

Clinical isolates of different Enterobacteriaceae strains and genetically modified variants which were resistant to the disinfectant formaldehyde were investigated. In cell-free extracts of all formaldehyde-resistant strains a glutathione-dependent formaldehyde dehydrogenase activity was demonstrate...

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Bibliographic Details
Published in:FEMS microbiology letters 1991-04, Vol.63 (2-3), p.335-338
Main Authors: Kaulfers, P M, Marquardt, A
Format: Article
Language:English
Subjects:
Aldehyde Oxidoreductases - metabolism
Cell-Free System
Disinfectants
Drug Resistance, Microbial
Enterobacteriaceae - drug effects
Enterobacteriaceae - enzymology
Formaldehyde - pharmacology
Glutathione - metabolism
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Summary:Clinical isolates of different Enterobacteriaceae strains and genetically modified variants which were resistant to the disinfectant formaldehyde were investigated. In cell-free extracts of all formaldehyde-resistant strains a glutathione-dependent formaldehyde dehydrogenase activity was demonstrated. In contrast cell extracts from formaldehyde sensitive strains did not show any formaldehyde dehydrogenase activity. The enzymatic degradation of formaldehyde seems to play an important role in formaldehyde resistance.
ISSN:0378-1097
DOI:10.1016/0378-1097(91)90108-M