Effect of atropine and d-tubocurarine on the monosynaptic connections between identified neurons in the central nervous system of the edible snail

Monosynaptically connected (MSC) neurons present a unique opportunity for the study not only of their specific properties, but of the features of the identified connections between them as well. In the present study, the effect of atropine and d-tubocurarine, blockers of cholinergic transmission, on...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience and behavioral physiology 1991-01, Vol.21 (1), p.37-38
Main Authors: Ter-Markaryan, A G, Palikhova, T A, Sokolov, E N
Format: Article
Language:English
Subjects:
Animals
Atropine - pharmacology
Central Nervous System - drug effects
Evoked Potentials - drug effects
In Vitro Techniques
Mytilus edulis
Neurons - drug effects
Parasympathetic Nervous System - drug effects
Parasympathetic Nervous System - physiology
Snails - physiology
Synapses - drug effects
Synaptic Transmission - drug effects
Tubocurarine - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monosynaptically connected (MSC) neurons present a unique opportunity for the study not only of their specific properties, but of the features of the identified connections between them as well. In the present study, the effect of atropine and d-tubocurarine, blockers of cholinergic transmission, on the monosynaptic connections between the presynaptic LPa7 and LPa9 neurons and the LPa3 command neuron was investigated with the aim of identifying the mediator. While the activity of pre- and postsynaptic neurons were simultaneously recorded intracellularly, a suprathreshold pulse of depolarizing current was delivered to the presynaptic cell through a recording microelectrode, eliciting in it an action potential (AP), in response to which an excitatory postsynaptic potential (EPSP) appeared in the postsynaptic command neuron.
ISSN:0097-0549
1573-899X
DOI:10.1007/BF01184236