Comparative performance of 14-crown-4 derivatives as lithium-selective electrodes

A series of neutral ionophore-based lithium-selective liquid-membrane electrodes have been prepared and the electrode performance compared with similar electrodes based on the lithium ionophores ETH 1810-ortho-nitrophenyl octyl ether (oNPOE) and ETH 2137-bis(1-butylpentyl) adipate (BBPA). By using a...

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Bibliographic Details
Published in:Analyst (London) 1991-02, Vol.116 (2), p.135-140
Main Authors: KATAKY, R, NICHOLSON, P. E, PARKER, D, COVINGTON, A. K
Format: Article
Language:English
Subjects:
Analytical biochemistry: general aspects, technics, instrumentation
Analytical, structural and metabolic biochemistry
Autoanalysis - methods
Biological and medical sciences
Bipolar Disorder - blood
Bipolar Disorder - drug therapy
Electrodes
Ethers, Cyclic
Fundamental and applied biological sciences. Psychology
Humans
Ionophores
Lithium - blood
Lithium - therapeutic use
Lithium Carbonate
Membranes, Artificial
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Summary:A series of neutral ionophore-based lithium-selective liquid-membrane electrodes have been prepared and the electrode performance compared with similar electrodes based on the lithium ionophores ETH 1810-ortho-nitrophenyl octyl ether (oNPOE) and ETH 2137-bis(1-butylpentyl) adipate (BBPA). By using a diamide substituted 14-crown-4 macrocycle, selectivities for Li+ in the presence of Na+ of log kpotLi,Na = -3.25 and -2.92 were obtained for diisobutylamide-oNPOE and di-n-butylamide-oNPOE derivatives. The di-n-butylamide-oNPOE based electrode functioned satisfactorily in serum, exhibiting a fast response time (10-15 s), an acceptable lifetime of 50 d and minimal protein interference.
ISSN:0003-2654
1364-5528
DOI:10.1039/an9911600135