The prognostic significance of glial fibrillary acidic protein staining in medulloblastoma

Histologic and immunohistochemical properties of 53 medulloblastomas were analyzed with regard to clinical features and survival rate. No correlation was found between survival rate and histologic features of the tumor, such as desmoplastic reaction, number of mitoses, hemorrhages, necrosis, endothe...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1991-08, Vol.68 (3), p.568-573
Main Authors: Goldberg‐Stern, Hadassa, Gadoth, Natan, Stern, Sidi, Sandbank, Uri, Cohen, Ian J., Zaizov, Rina
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cerebellar Neoplasms - chemistry
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - surgery
Child
Child, Preschool
Female
Glial Fibrillary Acidic Protein - analysis
Humans
Immunoenzyme Techniques
Infant
Male
Medulloblastoma - chemistry
Medulloblastoma - pathology
Medulloblastoma - surgery
Prognosis
Survival Analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Histologic and immunohistochemical properties of 53 medulloblastomas were analyzed with regard to clinical features and survival rate. No correlation was found between survival rate and histologic features of the tumor, such as desmoplastic reaction, number of mitoses, hemorrhages, necrosis, endothelial proliferation, glomerular arrangement, calcifications, rosettes, or oligodendroglial cells. However 82% of the patients with positive glial fibrillary acidic protein (GFAP) staining in numerous tumor cells survived more than 5 years; only 30% survived that long if their tumor cells were GFAP negative (P = 0.0093). This significant difference was not related to the mode of therapeutic protocol used. The authors suggest that GFAP staining may be a useful prognostic tool in medulloblastoma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19910801)68:3<568::AID-CNCR2820680321>3.0.CO;2-3