Comparison of anti-platelet properties of molsidomine, isosorbide-5-mononitrate and placebo in healthy volunteers

The purpose of the present work was to investigate the ex vivo platelet-inhibiting properties of the nitric oxide-containing vasodilator, molsidomine, and the organic nitrate, isosorbide-5-mononitrate, in comparison with placebo. Ex vivo platelet aggregation in 11 healthy volunteers was measured bef...

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Bibliographic Details
Published in:European heart journal 1991-04, Vol.12 (4), p.541-549
Main Authors: DRUMMER, C., VALTA-SEUFZER, U., KARRENBROCK, B., HEIM, J. M., GERZER, R.
Format: Article
Language:English
Subjects:
Adult
Aggregation
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Bleeding Time
Cardiovascular system
Cyclic GMP - blood
Dose-Response Relationship, Drug
Double-Blind Method
EDRF
Female
Humans
Isosorbide Dinitrate - analogs & derivatives
Isosorbide Dinitrate - blood
Isosorbide Dinitrate - pharmacology
Male
Medical sciences
Molsidomine - blood
Molsidomine - pharmacology
nitrates
Pharmacology. Drug treatments
Platelet Activating Factor - pharmacology
Platelet Aggregation Inhibitors
platelets
Random Allocation
Reference Values
thromboxane
Thromboxane B2 - blood
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Summary:The purpose of the present work was to investigate the ex vivo platelet-inhibiting properties of the nitric oxide-containing vasodilator, molsidomine, and the organic nitrate, isosorbide-5-mononitrate, in comparison with placebo. Ex vivo platelet aggregation in 11 healthy volunteers was measured before, as well as 30 and 60 min after, the intake of either 4mg molsidomine, 20 mg isosorbide-5-mononitrate (ISMN) or placebo in a randomized double-blind fashion. The release of thromboxane was also determined. Threshold doses of platelet-activating factor (PAF) to induce irreversible aggregation were significantly increased by 100 and 120% 30 and 60 min after molsidomine. Slopes of aggregation curves (aggregation induced with 50 and 200 nM PAF) were significantly reduced after molsidomine (P
ISSN:0195-668X
1522-9645
DOI:10.1093/oxfordjournals.eurheartj.a059936