The effect of a new antiarrhythmic agent, flecainide acetate, on systolic time intervals

We investigated the effect of flecainide on systolic time intervals in 6 healthy subjects. A randomized, double blind, cross-over study was designed using flecainide (2 mg/kg), propranolol (0.2 mg/kg) or saline. In comparison with placebo, flecainide increased heart rate, diastolic BP, QT-Index, QS2...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1983, Vol.25 (1), p.13-18
Main Authors: Muhiddin, K A, Shaw, E, Blackett, A, Patel, L, Turner, P
Format: Article
Language:English
Subjects:
Adult
Anti-Arrhythmia Agents - pharmacology
Blood Pressure - drug effects
Electrocardiography
Flecainide
Heart Rate - drug effects
Humans
Male
Piperidines - pharmacology
Systole - drug effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the effect of flecainide on systolic time intervals in 6 healthy subjects. A randomized, double blind, cross-over study was designed using flecainide (2 mg/kg), propranolol (0.2 mg/kg) or saline. In comparison with placebo, flecainide increased heart rate, diastolic BP, QT-Index, QS2-Index, PEP, and reduced LVET-Index (p less than 0.05). It caused a significant increase in PR interval, QRS duration, and PEP/LVET (p less than 0.01). Propranolol, compared with placebo, decreased heart rate and systolic BP (p less than 0.05). It increased PR interval, PEP, and PEP/LVET ratio (p less than 0.05). In comparison with propranolol, flecainide increased heart rate and QRS duration (p less than 0.01, p less than 0.001 respectively). It increased diastolic BP, PR interval, QS2-Index, PEP, and PEP/LVET ratio, and decreased LVET-Index (p less than 0.05). These changes in STI induced by flecainide may be produced by depression of myocardial contractility. Intraventricular conduction delay may be an additional contributing factor.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00544007