Development and bioevaluation of ( o)- 82Br[ 77Br]-bromohippuran

We show that ( o)-[ 82/77Br]bromohippuran ([ 82/77Br]-C 6H 4CONHCH 2COONa) with unlabelled ( o)-iodohippuran (I-C 6H 4CONHCH 2COONa) as carrier has in vivo properties analogous to ( o)-[ 131I]iodohippuran in rabbits and mice, while 77Br has some chemical, nuclidic and physiological advantages over 1...

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Bibliographic Details
Published in:The International journal of applied radiation and isotopes 1983-07, Vol.34 (7), p.1019-1021
Main Authors: van Wyk, A.J., Bekker, P., Niemann, D., Roesch, H., Fourie, P.J., Haasbroek, F.J., Venter, S.S.J.
Format: Article
Language:English
Subjects:
Animals
Bromine - metabolism
Iodohippuric Acid - analogs & derivatives
Iodohippuric Acid - blood
Iodohippuric Acid - metabolism
Isotope Labeling - methods
Mice
Rabbits
Radioisotopes - metabolism
Tissue Distribution
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Summary:We show that ( o)-[ 82/77Br]bromohippuran ([ 82/77Br]-C 6H 4CONHCH 2COONa) with unlabelled ( o)-iodohippuran (I-C 6H 4CONHCH 2COONa) as carrier has in vivo properties analogous to ( o)-[ 131I]iodohippuran in rabbits and mice, while 77Br has some chemical, nuclidic and physiological advantages over 131I. This particular study was sufficiently encouraging to warrant a separate follow up study, currently in progress, with more advanced investigations on animals, while the main objective is eventual clinical trials, including whole body dosimetry studies.
ISSN:0020-708X
DOI:10.1016/0020-708X(83)90085-6