An unusual transmissible agent - MaTu

MaTu is an agent, believed to be derived from a human mammary carcinoma, which displayed several extraordinary properties. These were: RIP and PAGE revealed in MaTu-infected cells only a single protein band of Mr 58 k, the gp 58. This gp 58 was immunoprecipitated by antibodies present in some human...

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Bibliographic Details
Published in:Archives of virology 1991-01, Vol.118 (3-4), p.189-197
Main Authors: ZAVADA, J, ZAVADORA, Z
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Antibodies, Viral - immunology
Biological and medical sciences
Defective Viruses - analysis
Defective Viruses - isolation & purification
Defective Viruses - pathogenicity
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
HeLa Cells
Helper Viruses
Humans
Immune Sera
Leukemia Virus, Murine
Microbiology
Miscellaneous
Precipitin Tests
Rabbits
Retroviridae - analysis
Retroviridae - isolation & purification
Retroviridae - pathogenicity
Sheep
Tumor Cells, Cultured
Vesicular stomatitis Indiana virus - analysis
Vesicular stomatitis Indiana virus - isolation & purification
Vesicular stomatitis Indiana virus - pathogenicity
Viral Proteins - analysis
Virology
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Description
Summary:MaTu is an agent, believed to be derived from a human mammary carcinoma, which displayed several extraordinary properties. These were: RIP and PAGE revealed in MaTu-infected cells only a single protein band of Mr 58 k, the gp 58. This gp 58 was immunoprecipitated by antibodies present in some human sera as well as in some sera of rabbits, sheep, and cattle. MaTu had an extremely restricted host range: it was transmissible only to HeLa cells, but not to human embryo fibroblasts, to three human tumour cell lines (T 47 D, T 24, and HMB 2) or to monkey Vero and rabbit SIRC cells. A retrovirus with a broad host range, used as a helper (X-MLV) enabled the transmission of MaTu to human fibroblasts, but not to Vero or SIRC, which are also permissive for X-MLV. These observations, together with our previous reports, support the view that MaTu might either be a novel type of defective virus, or even a non-viral autonomous genetic element.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01314029