Polyamines regulate calcium fluxes in a rapid plasma membrane response

Activation of cell-surface receptors often evokes changes in Ca 2+ fluxes leading to an increase in cytosolic Ca 2+ , a generally accepted mediator of many cell responses 1–3 . The molecular mechanisms by which surface agonists elicit these changes in Ca 2+ flux have remained elusive. An increase in...

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Bibliographic Details
Published in:Nature (London) 1983-01, Vol.305 (5934), p.530-534
Main Authors: Koenig, Harold, Goldstone, Alfred, Lu, Chung Y.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Transport - drug effects
calcium
Calcium - physiology
Cell Membrane - physiology
Deoxyglucose - metabolism
Eflornithine
Endocytosis - drug effects
Female
Fundamental and applied biological sciences. Psychology
Humanities and Social Sciences
kidney
Kidney - physiology
Kinetics
letter
Mice
multidisciplinary
Ornithine - analogs & derivatives
Ornithine - pharmacology
Ornithine Decarboxylase - biosynthesis
Ornithine Decarboxylase Inhibitors
polyamines
Polyamines - physiology
Putrescine - pharmacology
Science
Science (multidisciplinary)
Testosterone - antagonists & inhibitors
Testosterone - pharmacology
Vertebrates: urinary system
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Summary:Activation of cell-surface receptors often evokes changes in Ca 2+ fluxes leading to an increase in cytosolic Ca 2+ , a generally accepted mediator of many cell responses 1–3 . The molecular mechanisms by which surface agonists elicit these changes in Ca 2+ flux have remained elusive. An increase in the polyamines putrescine, spermidine and spermine, and their rate-regulating, synthetic enzyme ornithine decarboxylase (ODC), is one of the earliest events that occur during cell growth, replication and differentiation 4–6 . However, the precise physiological roles of the polyamines remain enigmatic 4–6 . Recently, we found that testosterone induces an early (
ISSN:0028-0836
1476-4687
DOI:10.1038/305530a0