Increased Incidence of Solid Malignant Tumors After Bone Marrow Transplantation for Severe Aplastic Anemia

From May 1980 to December 1989,107 consecutive patients with non-constitutional severe aplastic anemia underwent bone marrow transplantation at our institution using cyclophosphamide and thoraco-abdominal irradiation as conditioning regimen. During the same period, 40 patients with Fanconi anemia we...

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Bibliographic Details
Published in:Blood 1991-07, Vol.78 (2), p.277-279
Main Authors: Socie, G., Henry-Amar, M., Cosset, J.M., Devergie, A., Girinsky, T., Gluckman, E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anemia, Aplastic - surgery
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Fanconi Anemia - surgery
Female
Follow-Up Studies
Humans
In Vitro Techniques
Incidence
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - epidemiology
Neoplasms - etiology
Retrospective Studies
Tumors
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Description
Summary:From May 1980 to December 1989,107 consecutive patients with non-constitutional severe aplastic anemia underwent bone marrow transplantation at our institution using cyclophosphamide and thoraco-abdominal irradiation as conditioning regimen. During the same period, 40 patients with Fanconi anemia were also grafted after a similar conditioning, giving a total series of 147 patients. With a mean follow-up of 64 months, four male patients developed a solid malignant tumor, a number that leads to an 8-year cumulative incidence rate of 22% (eg, relative risk to general population = 41, P < .001). These results should be considered as a warning to clinicians who follow these successfully grafted long-term patients.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V78.2.277.277