Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28 SIS , closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28 SIS rapidly undergoes a series of discrete processing steps including dimer formation and prote...

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Bibliographic Details
Published in:Nature (London) 1983-10, Vol.305 (5935), p.605-608
Main Authors: Robbins, Keith C, Antoniades, Harry N, Devare, Sushilkumar G, Hunkapiller, Michael W, Aaronson, Stuart A
Format: Article
Language:English
Subjects:
AIDS/HIV
Amino Acid Sequence
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Fundamental and applied biological sciences. Psychology
Genes, Viral
Humanities and Social Sciences
Humans
Kinetics
Molecular and cellular biology
Molecular Weight
multidisciplinary
Platelet-Derived Growth Factor - genetics
Protein Processing, Post-Translational
Retroviridae - genetics
Sarcoma Virus, Woolly Monkey - genetics
Science
Science (multidisciplinary)
simian sarcoma virus
Structure-Activity Relationship
Viral Proteins - genetics
Viral Proteins - isolation & purification
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Summary:The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28 SIS , closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28 SIS rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yield molecules structurally and immunologically resembling biologically active PDGF.
ISSN:0028-0836
1476-4687
DOI:10.1038/305605a0