Intracellular Recordings from Cochlear Inner Hair Cells: Effects of Stimulation of the Crossed Olivocochlear Efferents

Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kiloh...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-10, Vol.222 (4619), p.69-72
Main Authors: Brown, M. Christian, Nuttall, Alfred L., Masta, Robert I.
Format: Article
Language:English
Subjects:
Afferent neurons
Afferent Pathways - physiology
Animals
Audio frequencies
Biological and medical sciences
Cochlea
Cochlea - physiology
Ear
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Hair cells
Hair Cells, Auditory - physiology
Hair Cells, Auditory, Inner - physiology
Hearing - physiology
Inner hair cells
Innervation
Neurons
Neurophysiology
Outer hair cells
Receptors
Sound pressure
Vertebrates: nervous system and sense organs
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Summary:Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kilohertz. Electrical stimulation of efferent nerves in the crossed olivocochlear bundle markedly reduced these receptor potentials while causing little change in the resting membrane potential. At high sound levels, where cells responded to an increasingly wider range of sound frequencies, stimulation was less effective in reducing receptor potentials. Since the crossed olivocochlear bundle primarily innervates outer hair cells, these results support an outer hair cell contribution to the most sensitive response region of inner hair cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6623058