Intrauterine multisystem atrophy in siblings: a new genetic syndrome?

A condition is described in two siblings, dying in early infancy, characterized by an extreme degree of cerebellar hypoplasia, hypoplasia or atrophy of the brain stem with partial preservation of cranial and spinal nerve nuclei, total degeneration of basal ganglia and thalamus, laminar atrophy of th...

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Bibliographic Details
Published in:Acta neuropathologica 1983-01, Vol.61 (1), p.65-70
Main Authors: Herrick, M K, Strefling, A M, Urich, H
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - pathology
Astrocytes - pathology
Atrophy
Autopsy
Basal Ganglia - abnormalities
Brain Stem - abnormalities
Cerebellum - abnormalities
Cerebral Cortex - abnormalities
Female
Humans
Infant, Newborn
Macrophages - pathology
Syndrome
Thalamus - abnormalities
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Summary:A condition is described in two siblings, dying in early infancy, characterized by an extreme degree of cerebellar hypoplasia, hypoplasia or atrophy of the brain stem with partial preservation of cranial and spinal nerve nuclei, total degeneration of basal ganglia and thalamus, laminar atrophy of the cerebral cortex, and accumulation of sudanophil lipid in astrocytes and macrophages of the hemispheric white matter. It is suggested that this condition, possibly inherited as an autosomal recessive, may represent a progressive multisystem atrophy occurring in utero, affecting various parts of the neuraxis in different stages in their development.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00688388