Increased virulence of modified-live infectious laryngotracheitis vaccine virus following bird-to-bird passage

Modified-live (ML) infectious laryngotracheitis (ILT) vaccine viruses, both tissue-culture-origin (TCO) and chicken-embryo-origin (CEO), were passaged 20 times in specific-pathogen-free chickens. After serial bird-to-bird passage, increased virulence was observed for CEO virus but not TCO virus. Inc...

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Bibliographic Details
Published in:Avian diseases 1991-04, Vol.35 (2), p.348-355
Main Authors: Guy, J.S. (North Carolina State University, Raleigh, NC), Barnes, H.J, Smith, L
Format: Article
Language:English
Subjects:
Animals
AVES DE CORRAL
Chickens
Chief executive officers
CULTIVO DE TEJIDOS
CULTURE DE TISSU
EMBRIONES ANIMALES
EMBRYON ANIMAL
Herpesviridae Infections - microbiology
Herpesviridae Infections - pathology
Herpesviridae Infections - veterinary
Herpesvirus 1, Gallid - immunology
Herpesvirus 1, Gallid - pathogenicity
Inoculation
LARINGOTRAQUEITIS
LARYNGOTRACHEITE
Lesions
Mortality
PODER PATOGENO
POLLITO
Poultry Diseases - microbiology
Poultry Diseases - pathology
POUSSIN
POUVOIR PATHOGENE
Respiratory diseases
Respiratory Tract Infections - microbiology
Respiratory Tract Infections - pathology
Respiratory Tract Infections - veterinary
Serial Passage
Specific Pathogen-Free Organisms
Trachea
Trachea - pathology
VACCIN VIVANT
Vaccination
VACUNA VIVA
Viral Vaccines - adverse effects
Virulence
Viruses
VOLAILLE
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Description
Summary:Modified-live (ML) infectious laryngotracheitis (ILT) vaccine viruses, both tissue-culture-origin (TCO) and chicken-embryo-origin (CEO), were passaged 20 times in specific-pathogen-free chickens. After serial bird-to-bird passage, increased virulence was observed for CEO virus but not TCO virus. Increased mortality and increased severity and duration of respiratory disease were observed in chickens inoculated with chicken-passaged CEO viruses; only mild respiratory disease (no mortality) occurred in chickens inoculated with chicken-passaged TCO viruses. These findings suggest that ML ILT vaccine viruses may increase in virulence after bird-to-bird passage
ISSN:0005-2086
1938-4351
DOI:10.2307/1591188