Familial juvenile polyposis coli and colorectal cancer

A 40‐year‐old mother and her 7‐year‐old son underwent colectomy for polyposis coli. Both colectomy specimens contained predominantly juvenile polyps. The mother's specimen also had numerous tubular adenomas and one 5‐cm severely dysplastic villous adenoma without invasive carcinoma. Foci of ade...

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Bibliographic Details
Published in:Cancer 1991-08, Vol.68 (4), p.889-892
Main Authors: O'Riordain, Diarmuid S., O'Dwyer, P. J., Cullen, A. F., McDermott, E. W., Murphy, J. J.
Format: Article
Language:English
Subjects:
Adenomatous Polyposis Coli - pathology
Adult
Child
Colorectal Neoplasms - pathology
Female
Humans
Male
Precancerous Conditions
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Summary:A 40‐year‐old mother and her 7‐year‐old son underwent colectomy for polyposis coli. Both colectomy specimens contained predominantly juvenile polyps. The mother's specimen also had numerous tubular adenomas and one 5‐cm severely dysplastic villous adenoma without invasive carcinoma. Foci of adenomatous change in juvenile polyps were present in the son's specimen. The histologic features of both cases suggest a sequence of change from juvenile polyps to adenomatous polyps to cancer.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19910815)68:4<889::AID-CNCR2820680435>3.0.CO;2-0