Prevalence and prognostic significance of silent and symptomatic ischemia after coronary bypass surgery: A report from the Coronary Artery Surgery Study (CASS) randomized population

• Published in: Journal of the American College of Cardiology 1991-08, Vol.18 (2), p.343-348
• Main Authors: Weiner, Donald A., Ryan, Thomas J., Parsons, Lori, Fisher, Lloyd D., Chaitman, Bernard R., Sheffield, L.Thomas, Tristani, Felix E.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Coronary Artery Bypass; Coronary Disease - epidemiology; Exercise Test; Female; Humans; Male; Medical sciences; Middle Aged; Postoperative Complications - epidemiology; Prevalence; Prognosis; Prospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Survival Analysis; Time Factors
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/0735-1097(91)90584-V

The prevalence and prognostic significance of postoperative myocardial ischemia, as detected by exercise testing, were prospectively assessed in 174 patients from the Coronary Artery Surgery Study (CASS) randomized surgical population who had exercise testing before and 6 months after coronary artery bypass graft surgery. Whereas the prevalence of symptomatic ischemia significantly decreased postoperatively (52% vs. 6%, p < 0.001), the frequency of silent myocardial ischemia did not change (30% vs. 29%). Survival at 12 years after bypass surgery based on the 6-month postoperative exercise, test results was significantly better for the 112 patients with no ischemia (80%) than for the 51 patients with silent ischemia (68%) or the 11 patients with symptomatic ischemia (45%). These data show that coronary artery bypass graft surgery diminishes the overall prevalence of symptomatic but not silent ischemia and that both silent and symptomatic ischemia adversely affect the postoperative prognosis of these patients.