The presence of peptide histidine-isoleucine in human, dog, guinea-pig and rat pancreas

Peptide histidine isoleucine-like immunoreactivity has been detected in the pancreas of man (10.3 +/- 2.6 pmol/g), dog (6.5 +/- 1.1 pmol/g), guinea-pig (5.8 +/- 0.9 pmol/g) and rat (0.7 +/- 0.1 pmol/g) using a specific radioimmunoassay. Chromatographic analysis of the pancreatic extracts by high per...

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Bibliographic Details
Published in:Diabetologia 1983-08, Vol.25 (2), p.125-127
Main Authors: Yiangou, Y, Christofides, N D, Evans, J E, Bloom, S R
Format: Article
Language:English
Subjects:
Animals
Chromatography, Gel
Chromatography, High Pressure Liquid
Dogs
Guinea Pigs
Humans
Pancreas - analysis
Peptide PHI
Peptides - analysis
Radioimmunoassay
Rats
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Description
Summary:Peptide histidine isoleucine-like immunoreactivity has been detected in the pancreas of man (10.3 +/- 2.6 pmol/g), dog (6.5 +/- 1.1 pmol/g), guinea-pig (5.8 +/- 0.9 pmol/g) and rat (0.7 +/- 0.1 pmol/g) using a specific radioimmunoassay. Chromatographic analysis of the pancreatic extracts by high performance liquid chromatography indicated that both guinea-pig and rat have a molecular form of the immunoreactivity which is distinct from the porcine intestinal peptide histidine-isoleucine.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00250901