Antineoplastic Agents, 88. Pimelea prostrata

The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 X 10(-3) and 8 X 10(-4) mi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1983-07, Vol.46 (4), p.563-568
Main Authors: Pettit, George R, Zou, Ji-Chun, Goswami, Animesh, Cragg, Gordon M, Schmidt, Jean M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - analysis
Chemical Phenomena
Chemistry
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Mice
Plants, Medicinal - analysis
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Summary:The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 X 10(-3) and 8 X 10(-4) micrograms/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) was also found to inhibit growth (T/C 132 at 20 micrograms/kg) of the PS in vivo system. Detailed 1H-nmr (at 400 MHz) and 13C-nmr studies combined with fast atom bombardment mass spectral evidence were employed to confirm the structural assignments.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50028a024