The effect of spinal implant rigidity on vertebral bone density : a canine model

• Published in: Spine (Philadelphia, Pa. 1976) Pa. 1976), 1991-06, Vol.16 (6S), p.S190-S197
• Main Authors: MCAFEE, P. C, FAREY, I. D, SUTTERLIN, C. E, GURR, K. R, WARDEN, K. E, CUNNINGHAM, B. W
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Biomechanical Phenomena; Bone Density; Bone Transplantation; Bone Wires; Dogs; Female; Injuries of the limb. Injuries of the spine; Internal Fixators; Lumbar Vertebrae - pathology; Lumbar Vertebrae - surgery; Medical sciences; Osteoporosis - etiology; Ovariectomy; Spinal Fusion - adverse effects; Spinal Fusion - instrumentation; Traumas. Diseases due to physical agents
• ISSN: 0362-2436; 1528-1159
• DOI: 10.1097/00007632-199106001-00003

An animal model of anterior and posterior column instability was developed to allow in vivo observation of bone remodeling and arthrodesis following spinal instrumentation. After an initial anterior and posterior destabilizing lesion was created at the L5-L6 vertebral levels in 63 adult beagles, various spinal reconstructive surgical procedures were performed--with or without bilateral posterolateral bone grafting, with or without bilateral oophorectomies, and with or without spinal instrumentation (Harrington distraction, Luque rectangular, Cotrel-Dubousset pedicular, or Steffee pedicular implants). Observation 6 months after surgery revealed a significantly improved probability of achieving a spinal fusion if spinal instrumentation had been used (X2 = 5.84, P = .016). Nondestructive mechanical testing after removal of all metal instrumentation in torsion, axial compression, and flexion revealed that the fusions performed in conjunction with spinal instrumentation were more rigid (P less than .05). Quantitative histomorphometry showed that the volumetric density of bone was significantly lower (ie, device-related osteoporosis occurred) for fused versus unfused spines. In addition, a linear correlation occurred between decreasing volumetric density of bone and increasing rigidity of the spinal implant (r = .778); ie, device-related osteoporosis occurred secondary to Harrington, Cotrel-Dubousset, and Steffee pedicular instrumentation. Oophorectomized dogs became more osteoporotic than their surgically matched controls (posterolateral bone grafting alone, Cotrel-Dubousset pedicular instrumentation, and Steffee pedicular instrumentation); device-related osteoporosis added to the degree of hormonally induced osteoporosis (t = 5.0, P less than .0001). This is the first study to date documenting the occurrence of stress shielding in the spine secondary to spinal instrumentation.