Curved Anaerobic Bacteria in Bacterial (Nonspecific) Vaginosis and Their Response to Antimicrobial Therapy

Vaginal fluid samples from normal college students, college students with bacterial (nonspecific) vaginosis, and sexually transmitted disease clinic patients with bacterial vaginosis, before and after therapy with metronidazole, ampicillin, or amoxicillin, were evaluated by direct Gram stain and cul...

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Bibliographic Details
Published in:The Journal of infectious diseases 1983-11, Vol.148 (5), p.817-822
Main Authors: Spiegel, Carol A., Eschenbach, David A., Amsel, Richard, Holmes, King K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anaerobic bacteria
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial vaginosis
Biological and medical sciences
Cefoxitin - pharmacology
Clindamycin - pharmacology
Clinical Investigation
College students
Drug Resistance, Microbial
Female
Flora
Humans
Medical sciences
Metronidazole - pharmacology
Microbial Sensitivity Tests
Moxalactam - pharmacology
Pharmacology. Drug treatments
Sexually transmitted diseases
Starches
Vagina
Vagina - microbiology
Vaginitis
Vaginitis - drug therapy
Vaginitis - microbiology
Vancomycin - pharmacology
Vibrio
Vibrio - cytology
Vibrio - drug effects
Vibrio - isolation & purification
Vibrio Infections - drug therapy
Vibrio Infections - microbiology
Wolinella
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Summary:Vaginal fluid samples from normal college students, college students with bacterial (nonspecific) vaginosis, and sexually transmitted disease clinic patients with bacterial vaginosis, before and after therapy with metronidazole, ampicillin, or amoxicillin, were evaluated by direct Gram stain and culture for the predominant anaerobic and facultative flora. Curved rods were detectedby direct Gram stain of vaginalfluid from 31(51%) of 61 women with bacterial vaginosis and none of 42 normal student controls (P < 0.001). Curved, gram-variable to gram-negative organisms were recovered from six of these 31 women, seven other women with bacterial vaginosis, and no controls. All 13 isolates were anaerobic, motile, and oxidase-negative, produced succinic acid as their major metabolic product, and hydrolyzed starch. After treatment with ampicillin or amoxicillin (n = 10) or ⩾2 g of metronidazole (n = 9), no curved motile rods were detected by Gram stain or culture, although the minimal inhibitory concentration of metronidazole was ⩾8 µg/ml for 11 of the 13 isolates tested.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/148.5.817