Quantitative measurement of uptake of radiolabeled monoclonal antibody by means of planar data

Data obtained from planar images were used to measure the uptake of monoclonal antibody in organs and tumors. Background counts included in the region of interest were eliminated, and the attenuation of the photons emitted by the radionuclide through the intervening tissues was compensated for. The...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nuclear medicine 1991-03, Vol.5 (1), p.1-9
Main Authors: Akiyama, Y, Yui, N, Matsumoto, T, Iinuma, T A, Ikehira, H, Fukuda, H, Tateno, Y
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - pharmacokinetics
Antigens, Neoplasm - immunology
Bone Marrow - metabolism
Female
Humans
Indium Radioisotopes
Liver - metabolism
Melanoma - immunology
Melanoma - metabolism
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Data obtained from planar images were used to measure the uptake of monoclonal antibody in organs and tumors. Background counts included in the region of interest were eliminated, and the attenuation of the photons emitted by the radionuclide through the intervening tissues was compensated for. The background counts and the intensity of the attenuation were determined from the results of phantom studies and numerical integration with a personal computer. The quantitative uptake of 111In labeled anti-melanoma Monoclonal Antibody (ZME-018) in a melanoma lesion, the liver, and the bone marrow of a patient was measured by the planar method which we developed.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03164607