Antidiabetic activity of some 1-substituted 3,5-dimethylpyrazoles

Several new 1-substituted 3,5-dimethylpyrazoles were prepared for testing as hypoglycemic agents. A number of these containing para-substituted 1-carbonylphenylurea and para-substituted 1-carbamoylbenzenesulfonylurea derivatives were found to possess potent hypoglycemic activity.

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Bibliographic Details
Published in:Journal of medicinal chemistry 1983-11, Vol.26 (11), p.1659-1663
Main Authors: Soliman, Raafat, Darwish, Suzan A. S
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Chemistry
Diabetes Mellitus, Experimental - drug therapy
Drug Evaluation, Preclinical
Exact sciences and technology
Female
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Hypoglycemic Agents - chemical synthesis
Indicators and Reagents
Mice
Organic chemistry
Preparations and properties
Pyrazoles - chemical synthesis
Pyrazoles - therapeutic use
Structure-Activity Relationship
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Description
Summary:Several new 1-substituted 3,5-dimethylpyrazoles were prepared for testing as hypoglycemic agents. A number of these containing para-substituted 1-carbonylphenylurea and para-substituted 1-carbamoylbenzenesulfonylurea derivatives were found to possess potent hypoglycemic activity.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00365a023