Effect of immune reconstitution on resistance to Brugia pahangi in congenitally athymic nude mice

Brugia pahangi, resistance comparable to that exhibited by normal mice can be conferred upon nude mice by treatments that also partially reconstitute T lymphocyte functions and by adoptive transfer of spleen cells from infection-primed heterozygotes, serum containing anti-parasite antibodies was not...

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Bibliographic Details
Published in:The Journal of parasitology 1983-06, Vol.69 (3), p.478-485
Main Authors: Vickery, A.C, Vincent, A.L, Sodeman, W.A., jr
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies - immunology
Antigens
Brugia - immunology
Brugia pahangi
Concanavalin A - pharmacology
Female
Filariasis - immunology
Heterozygotes
immunity
Immunity, Innate
Immunization, Passive
Immunology
Infections
Inoculation
Larvae
Male
Mice
Mice, Inbred C3H
Mice, Nude
Parasite hosts
Parasites
passive immunity
Spleen - cytology
Spleen - immunology
Spleen cells
T lymphocytes
T-Lymphocytes - immunology
Technique, Experimental hosts
Thymus Gland - transplantation
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Summary:Brugia pahangi, resistance comparable to that exhibited by normal mice can be conferred upon nude mice by treatments that also partially reconstitute T lymphocyte functions and by adoptive transfer of spleen cells from infection-primed heterozygotes, serum containing anti-parasite antibodies was not protective in absence of transferred cells, B. pahangi infection in nude mice will be useful new model for study of immunobiology of lymphatic filarial parasites
ISSN:0022-3395
1937-2345
DOI:10.2307/3281358