Connection between foreign DNA replication and induced expression of the restriction-modification system inStreptomyces aureofaciens

Tetracycline-producing strains ofStreptomyces aureofaciens expressedSauLPI restriction-modification (R-M) system, which recognized specific DNA sequence 5′-GCCGGC-3′ (isoschizomerNaeI). The activation of the second R-M systemSauLPII (5′-GAGCTC-3′, isoschizomer ofXhoI), which was silent during the gr...

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Bibliographic Details
Published in:Folia microbiologica 2001-06, Vol.46 (3), p.193-196
Main Authors: Godány, A., Farkašovská, J., Bukovská, G., Timko, J.
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
DNA biosynthesis
Gene expression
Nucleotide sequence
Proteins
Replication
Restriction-modification
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Summary:Tetracycline-producing strains ofStreptomyces aureofaciens expressedSauLPI restriction-modification (R-M) system, which recognized specific DNA sequence 5′-GCCGGC-3′ (isoschizomerNaeI). The activation of the second R-M systemSauLPII (5′-GAGCTC-3′, isoschizomer ofXhoI), which was silent during the growth cycle, after a foreign DNA transfer into this strain was observed. This phenomenon was tentatively explained as a response of the cells against the exogenous DNA entering the cells. The involvement of a SOS-like response in induction of R-M system genes inS. aureofaciens strains has been considered.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02818532