Antibacterial effects of trisubstituted quinazoline derivatives

Five trisubstituted quinazolones and eight trisubstituted quinazoline-4-thiones have been tested for antibacterial effects by a microdilution method. Four derivatives exerted a significant effect on E. coli, P. aeruginosa, S. aureus and B. subtilis (IC₅₀

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Bibliographic Details
Published in:Folia microbiologica 2000-01, Vol.45 (2), p.133-137
Main Authors: Jantová, S, Greif, G, Špirková, K, Stankovský, Š, Oravcová, M
Format: Article
Language:English
Subjects:
Ampicillin
Anti-Bacterial Agents - pharmacology
Antibacterial activity
antibacterial properties
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antiinfectives and antibacterials
Bacillus subtilis - drug effects
Bacteria
Bacteria - drug effects
Bacteria - growth & development
Bacteriology
Biological and medical sciences
Derivatives
Escherichia coli - drug effects
Fundamental and applied biological sciences. Psychology
Growth rate
Medical sciences
Microbial Sensitivity Tests
Microbiology
Pharmacology. Drug treatments
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Quinazolines - chemistry
Quinazolines - pharmacology
specific growth rate
Staphylococcus aureus
Staphylococcus aureus - drug effects
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Summary:Five trisubstituted quinazolones and eight trisubstituted quinazoline-4-thiones have been tested for antibacterial effects by a microdilution method. Four derivatives exerted a significant effect on E. coli, P. aeruginosa, S. aureus and B. subtilis (IC₅₀
ISSN:0015-5632
1874-9356
DOI:10.1007/bf02817411