Rare genera of actinomycetes as potential producers of new antibiotics

A literature survey covering more than twenty-three thousand bioactive microbial products including eight thousand antiinfectives demonstrated the increasing relevance of the so called 'rare' actinomycetes as a source of new antibiotics. Past and present efforts in the isolation of rare ac...

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Bibliographic Details
Published in:Antonie van Leeuwenhoek 2000-12, Vol.78 (3-4), p.399-405
Main Authors: Lazzarini, A, Cavaletti, L, Toppo, G, Marinelli, F
Format: Article
Language:English
Subjects:
Actinomadura
Actinomycetales - classification
Actinomycetales - genetics
Actinomycetales - metabolism
Actinomycetes
Actinoplanes
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Antibiotics
Bacteria
Databases, Factual
Genetic Variation
Micromonospora
MICROTETRASPORA
Soil
Species Specificity
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Summary:A literature survey covering more than twenty-three thousand bioactive microbial products including eight thousand antiinfectives demonstrated the increasing relevance of the so called 'rare' actinomycetes as a source of new antibiotics. Past and present efforts in the isolation of rare actinomycetes have enriched the Biosearch Italia Strain Collection with more than twenty thousand strains, showing that, when selective isolation methods are developed and extensively applied, some genera, such as Actinomadura, Actinoplanes, Micromonospora, Microtetraspora, are not rare at all and can be recovered from many soil samples. The current focus is on the isolation of members of Streptosporangiaceae family, given their promising chemical diversity.
ISSN:0003-6072
1572-9699
DOI:10.1023/a:1010287600557