The mechanisms of activation of normal human serum complement byEscherichia coli strains with K1 surface antigen

TenE. coli K1 strains isolated from the urine of children with urinary tract infections were sensitive to the bactericidal action of normal human serum (NHS). The role of the particular mechanisms of complement activation was determined in the process of killing these strains, showing variable sensi...

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Bibliographic Details
Published in:Folia microbiologica 2006-11, Vol.51 (6), p.627-632
Main Authors: Bugla-Płoskońska, G., Cisowska, A., Karpińska, K., Jankowski, S., Doroszkiewicz, W.
Format: Article
Language:English
Subjects:
Bacterial infections
Bacteriology
Children & youth
E coli
Microbiology
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Summary:TenE. coli K1 strains isolated from the urine of children with urinary tract infections were sensitive to the bactericidal action of normal human serum (NHS). The role of the particular mechanisms of complement activation was determined in the process of killing these strains, showing variable sensitivity to the bactericidal action of NHS; three mechanisms of activation of human complement were observed. Important role of alternative pathway activation in the bactericidal action of NHS againstE. coli K1 strains independent of the classical and lectin pathways was not established.[PUBLICATION ABSTRACT]
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02931630