Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval

• Published in: Journal of antimicrobial chemotherapy 2010-10, Vol.65 (10), p.2128-2133
• Main Authors: den Heijer, C. D. J., Donker, G. A., Maes, J., Stobberingh, E. E.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; antibiotic use; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial agents; antimicrobial resistance; Bacterial diseases; Bacterial diseases of the urinary system; Biological and medical sciences; Child; community-acquired; Comparative analysis; cystitis; Drug Prescriptions - standards; Drug Prescriptions - statistics & numerical data; Drug Utilization - statistics & numerical data; E coli; ESBLs; Escherichia coli; Escherichia coli Infections - microbiology; Female; General Practice; Guideline Adherence - statistics & numerical data; Human bacterial diseases; Humans; Infectious diseases; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Nephrology. Urinary tract diseases; Netherlands; Pathogens; Pharmacology. Drug treatments; Prescriptions; Time Factors; Urinary system involvement in other diseases. Miscellaneous; Urinary tract diseases; Urinary Tract Infections - microbiology; Urinary tract. Prostate gland; Uropathogenic Escherichia coli - drug effects; Uropathogenic Escherichia coli - isolation & purification; Women; Young Adult
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkq286

Objectives To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary. We compared the antibiotic prescription rate for UTIs in women and the E. coli antibiotic susceptibility results, including the prevalence of extended-spectrum β-lactamase (ESBL)-producing strains, in 2009 with data collected 5 years earlier. Patients and methods Urinary samples from female patients with symptoms of uncomplicated UTI in 42 general practices were collected over a 6 month period. Uropathogens were identified and the antibiotic susceptibility of E. coli was determined. Results We analysed 970 urine cultures, of which 785 (81%) were considered positive (≥103 cfu/mL). E. coli accounted for 72% of the isolates. ESBLs showed an increase between the two surveys (0.1% versus 1%; P