Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations

Previous studies have shown that iron deficiency (ID) increases brain manganese (Mn), but specific regional changes have not been addressed. Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese fortified (IDMn+). Seven brain regions w...

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Bibliographic Details
Published in:Biological trace element research 2002, Vol.87 (1-3), p.143-156
Main Authors: Erikson, Keith M, Shihabi, Zakariya K, Aschner, Judy L, Aschner, Michael
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - metabolism
Animals
Body Weight
Brain
Brain - metabolism
Central nervous system
Deficiency Diseases - metabolism
Iron
Iron - deficiency
Male
Manganese
Manganese - metabolism
Manganese compounds
Neurochemistry
Nutrient deficiency
Organ Size
Parkinson's disease
Rats
Rats, Sprague-Dawley
Risk factors
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Summary:Previous studies have shown that iron deficiency (ID) increases brain manganese (Mn), but specific regional changes have not been addressed. Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese fortified (IDMn+). Seven brain regions were analyzed for Mn concentration and amino acid (glutamate, glutamine, taurine, gamma-aminobutyric acid) concentrations. Both ID and IDMn+ diets caused significant (p
ISSN:0163-4984
0163-4984
1559-0720
DOI:10.1385/BTER:87:1-3:143