Contribution of capsular and lipopolysaccharide antigens to the pathogenesis ofKlebsiella pneumoniae respiratory tract infection

The role ofKlebsiella pneumoniae K- and O-polysaccharide antigens was determined in a rat model of lobar pneumonia. The induction of experimental infection in rats by wild-type strain, and its lipopolysaccharide- and capsular polysaccharide-deficient mutants was compared. Though the mutant lacking b...

Full description

Saved in:
Bibliographic Details
Published in:Folia microbiologica 2003-09, Vol.48 (5), p.699-702
Main Authors: Chhibber, S, Aggarwal, S, Yadav, V
Format: Article
Language:English
Subjects:
Antigens
Bacteria
Capsular polysaccharides
Deficient mutant
Experimental infection
Lipopolysaccharides
Microbiology
Pathogenesis
Pneumonia
Polysaccharides
Respiratory tract
Respiratory tract diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role ofKlebsiella pneumoniae K- and O-polysaccharide antigens was determined in a rat model of lobar pneumonia. The induction of experimental infection in rats by wild-type strain, and its lipopolysaccharide- and capsular polysaccharide-deficient mutants was compared. Though the mutant lacking both antigens (K− O−) induced infection it could not successfully establish itself in the rat lung. It caused only mild infection, as compared to the wild type strain (K+ O+) and the strain lacking CPS alone (K− O+). Besides capsular polysaccharide, the lipopolysaccharide antigen was shown to be an important factor in pathogenesis ofK. pneumoniae acute respiratory tract infection.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02993481