Dietary Arsenic Affects Dimethylhydrazine-Induced Aberrant Crypt Formation and Hepatic Global DNA Methylation and DNA Methyltransferase Activity in Rats

Cell culture studies have suggested that arsenic exposure results in decreased S-adenosylmethionine (SAM), causing DNA hypomethylation. Previously, we have shown that hepatic SAM is decreased and/or S-adenosylhomocysteine increased in arsenic-deprived rats; these rats tended to have hypomethylated D...

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Bibliographic Details
Published in:Biological trace element research 2005-02, Vol.103 (2), p.133-145
Main Authors: Uthus, Eric O, Davis, Cindy
Format: Article
Language:English
Subjects:
abberant crypts
aberrant crypt foci
Animals
Arsenic
Arsenic - administration & dosage
Arsenic - toxicity
carcinogenesis
carcinogens
Carcinogens - toxicity
colon
Colon - anatomy & histology
Colon - drug effects
colorectal neoplasms
crypt formation
Deoxyribonucleic acid
Diet
Dietary minerals
dimethylhydrazine
Dimethylhydrazines - pharmacology
DNA
DNA hypomethyltion
DNA Methylation
DNA methyltransferase
DNA Modification Methylases - metabolism
Humans
ingestion
liver
Liver - drug effects
Liver - physiology
Male
methyltransferases
Rats
Rats, Inbred F344
Rodents
Vegetables
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Summary:Cell culture studies have suggested that arsenic exposure results in decreased S-adenosylmethionine (SAM), causing DNA hypomethylation. Previously, we have shown that hepatic SAM is decreased and/or S-adenosylhomocysteine increased in arsenic-deprived rats; these rats tended to have hypomethylated DNA. To determine, the effect of dietary arsenic on dimethylhydrazine (DMH)-induced aberrant crypt formation in the colon, Fisher 344 weanling male rats were fed diets containing 0,05, or 50 micrograms As (as NaAsO2)/g. After 12 wk, dietary arsenic affected the number of aberrant crypts (p
ISSN:1559-0720
0163-4984
1559-0720
0163-4984
DOI:10.1385/BTER:103:2:133