Effect of selenium on lead-induced alterations in rat brain

The effects of lead (Pb) and selenium (Se) interactions on central nervous system (CNS) functions were seen in adult rats by both biochemical and histologic pathological alterations. Pb administration of 20 mg/kg body wt for 8 wk showed degenerative changes only in the cerebral cortex. The changes i...

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Bibliographic Details
Published in:Biological trace element research 1997-06, Vol.57 (3), p.251-258
Main Authors: Nehru, B, Dua, R, Iyer, A
Format: Article
Language:English
Subjects:
Animals
Brain
Brain Chemistry - drug effects
Central nervous system
Cerebellum
Cerebellum - drug effects
Cerebellum - pathology
Cerebral cortex
Cerebral Cortex - drug effects
Cerebral Cortex - pathology
Deoxyribonucleic acid
DNA
DNA - analysis
Drug Interactions
Female
Lead
Lead - pharmacology
Lead - toxicity
Nervous system
Organ Size
Proteins - analysis
Rats
Ribonucleic acid
RNA
RNA - analysis
Rodents
Selenium
Selenium - pharmacology
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Summary:The effects of lead (Pb) and selenium (Se) interactions on central nervous system (CNS) functions were seen in adult rats by both biochemical and histologic pathological alterations. Pb administration of 20 mg/kg body wt for 8 wk showed degenerative changes only in the cerebral cortex. The changes in the cerebellar regions were not significant. Biochemically a marked decrease in the DNA, RNA, and protein content was seen following lead treatment. These decreases were significant in both the regions of the brain. During the concomitant administration of Pb and Se, the alterations in the transverse section of cerebral cortex showed only marginal changes. The values of DNA and RNA content showed significant improvement in both regions of the brain compared to the Pb treated group.
ISSN:0163-4984
1559-0720
DOI:10.1007/BF02785293