Effect of aluminum on superoxide dismutase activity in the adult rat brain

Male rats were treated daily with an intraperitoneal injection of 15 mg aluminum (Al chloride)/kg body weight for 17 d, in order to study the effects on superoxide dismutase (SOD) activities in the brain (cortex). No significant difference between control and treated animals was registered in the Cu...

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Bibliographic Details
Published in:Biological trace element research 1998-10, Vol.65 (1), p.19-30
Main Authors: Atienzar, F, Desor, D, Burnel, D, Keller, J M, Lehr, P, Vasseur, P
Format: Article
Language:English
Subjects:
Aluminium
Aluminum
Aluminum Compounds - blood
Aluminum Compounds - pharmacology
Animals
Body weight
Body weight gain
Brain
Cerebral Cortex - drug effects
Cerebral Cortex - enzymology
Cerebral Cortex - metabolism
Chlorides - blood
Chlorides - pharmacology
Copper
Cortex
Feeding Behavior - drug effects
Ingestion
Liver - metabolism
Male
Manganese
Microscopy, Electron
Mitochondria - enzymology
Rats
Rats, Wistar
Rodents
Spleen
Spleen - metabolism
Substantia grisea
Superoxide dismutase
Superoxide Dismutase - metabolism
Tissue Distribution
Weight Gain - drug effects
Zinc
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Summary:Male rats were treated daily with an intraperitoneal injection of 15 mg aluminum (Al chloride)/kg body weight for 17 d, in order to study the effects on superoxide dismutase (SOD) activities in the brain (cortex). No significant difference between control and treated animals was registered in the Cu/Zn and Mn SOD activities in the gray matter of the cortex. High Al levels were found in the plasma, the spleen, and the liver of the treated animals in comparison to the controls, but not in the cortex homogenates (gray matter). In addition, Al induced a significant decrease in food ingestion and weight gain.
ISSN:0163-4984
1559-0720
DOI:10.1007/BF02784111