Relationship between pressure passivity and subependymal/intraventricular hemorrhage as assessed by pulsed doppler ultrasound

A prospective study was undertaken using a range-gated, pulsed Doppler velocimeter to study flowpressure relationships in the anterior cerebral artery. Serial velocity and pressure studies were performed with each infant serving as his or her own control. The hypothesis tested was that ill preterm i...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1983-11, Vol.72 (5), p.665-669
Main Authors: AHMANN, P. A, DYKES, F. D, LAZZARA, A, HOLT, P. J, GIDDENS, D. P, CARRIGAN, T. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Flow Velocity
Blood Pressure
Cerebral Arteries - physiopathology
Cerebral Hemorrhage - physiopathology
Cerebral Ventricles
Cerebrovascular Circulation
Ependyma
Humans
Infant, Newborn
Infant, Premature, Diseases - physiopathology
Medical sciences
Neurology
Prospective Studies
Ultrasonography
Vascular diseases and vascular malformations of the nervous system
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Summary:A prospective study was undertaken using a range-gated, pulsed Doppler velocimeter to study flowpressure relationships in the anterior cerebral artery. Serial velocity and pressure studies were performed with each infant serving as his or her own control. The hypothesis tested was that ill preterm infants sustaining subependymal/intraventricular hemorrhage would have absent autoregulation. The hypothesis has been tested in 88 studies on 32 infants. Of 32 infants studied, 15 were judged to be pressure passive; nine of these children bled. The other 17 infants were not pressure passive; eight of these children bled (P greater than .05). From these studies, it may be concluded that the pressure passive state is not the final common link in the genesis of subependymal/intravertricular hemorrhage. Pulsed Doppler ultrasound may provide an extremely useful noninvasive technique for studying both the arterial and venous sides of the cerebral circulation.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.72.5.665