Evidence for the role of serotonin in the regulation of slow wave sleep in schizophrenia

Nocturnal sleep data and cerebrospinal fluid (CSF) concentrations of the biogenic amine metabolites were measured in 20 male schizophrenics. Consistent with other reports of a stage 4 sleep deficit in schizophrenia, measures of stage 4 sleep were low relative to normal reference data. Measures of st...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 1991-04, Vol.14 (2), p.133-139
Main Authors: BENSON, K. L, FAULL, K. F, ZARCONE, V. P
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Dopamine - metabolism
Hospitalization
Humans
Hydroxyindoleacetic Acid - cerebrospinal fluid
Hydroxyindoleacetic Acid - metabolism
Male
Medical sciences
Middle Aged
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia - cerebrospinal fluid
Schizophrenia - metabolism
Schizophrenia - physiopathology
Serotonin - cerebrospinal fluid
Serotonin - metabolism
Serotonin - physiology
Sleep Stages - physiology
Spinal Puncture
Time Factors
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Summary:Nocturnal sleep data and cerebrospinal fluid (CSF) concentrations of the biogenic amine metabolites were measured in 20 male schizophrenics. Consistent with other reports of a stage 4 sleep deficit in schizophrenia, measures of stage 4 sleep were low relative to normal reference data. Measures of stage 4 sleep in absolute amounts and corrected for total sleep were positively correlated with CSF concentrations of the serotonin metabolite, 5-hydroxyindole acetic acid (5-HIAA). CSF 5-HIAA was also correlated with measures of stage 3 sleep and total sleep time suggesting that serotonin may modulate the amount of slow wave sleep broadly defined and possibly sleep duration. Total stage 4 time was also correlated with the dopamine metabolite HVA; consequently, the specificity of the finding might be limited. Also, in this study, schizophrenia was used as a particular model for stage 4 deficits; however, the association of measures of stage 4 sleep with CSF levels of 5-HIAA is not thought to be specific to schizophrenia.
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/14.2.133