Absorption of methionine and methionine sulphoxide in rat intestine and the effect of glutathione

1. The absorption of methionine and methionine sulphoxide was compared in inverted rings from three sections of rat intestine. 2. In all sections, absorption of unoxidized methionine was 20–40% higher than that of methionine at low physiological substrate concentrations. At higher substrate levels,...

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Bibliographic Details
Published in:British journal of nutrition 1983-11, Vol.50 (3), p.583-588
Main Authors: Aksnes, A., Njaa, L. R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
food composition
food quality
Fundamental and applied biological sciences. Psychology
Glutathione - pharmacology
human nutrition
In Vitro Techniques
Intestinal Absorption - drug effects
Intestine, Small - metabolism
Intestine. Mesentery
Male
Methionine - analogs & derivatives
Methionine - metabolism
nutrition physiology
Rats
Time Factors
Vertebrates: digestive system
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Summary:1. The absorption of methionine and methionine sulphoxide was compared in inverted rings from three sections of rat intestine. 2. In all sections, absorption of unoxidized methionine was 20–40% higher than that of methionine at low physiological substrate concentrations. At higher substrate levels, the difference was not so pronounced. 3. Inhibition studies indicated that absorption of methionine and of methionine sulphoxide took place by different absorption systems. 4. Glutathione increased the absorption of methionine and, to a greater extent, the absorption of methionine sulphoxide.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN19830129