Dermatitis herpetiformis: a review of 119 cases

Summary Between 1954 and 1980 119 cases of dermatitis herpetiformis have been seen. IgA examination of uninvolved skin was positive in 93·6%, of patients. Jejunal biopsy showed villous atrophy in 6%, of patients. HLA typing showed HLA‐B8 present in 83·7%, HLA‐Ai in 74·4%, and HLA‐B8 or ‐Ai in 93%, o...

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Bibliographic Details
Published in:Clinical and experimental dermatology 1983-09, Vol.8 (5), p.477-487
Main Authors: BUCKLEY, D.B., ENGLISH, J., MOLLOY, W., DOYLE, C.T., WHELTON, M.J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Bullous diseases of the skin
Celiac Disease - complications
Child
Dermatitis Herpetiformis - complications
Dermatitis Herpetiformis - immunology
Dermatology
Female
HLA Antigens - analysis
Humans
Intestinal Neoplasms - complications
Lymphoma - complications
Male
Medical sciences
Middle Aged
Skin - immunology
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Summary:Summary Between 1954 and 1980 119 cases of dermatitis herpetiformis have been seen. IgA examination of uninvolved skin was positive in 93·6%, of patients. Jejunal biopsy showed villous atrophy in 6%, of patients. HLA typing showed HLA‐B8 present in 83·7%, HLA‐Ai in 74·4%, and HLA‐B8 or ‐Ai in 93%, of patients. Antinuclear factor was present in 19%, thyroid antibodies in 6%, and parietal cell antibodies in 8%, of the patients. Two out of twenty patients (10%) examined had anti‐reticulin antibodies. Twenty per cent of the patients had a positive family history of atopy, and 6%, had a positive personal history of it. Fourteen patients (11‐7%) had relatives with coeliac disease. A gluten‐free diet is advocated for all patients. Dapsone will control the rash if patients are unwilling to take the diet.
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.1983.tb01815.x