Cytogenetics of the human benign mixed salivary gland tumour

• Published in: Hereditas 1983-01, Vol.99 (1), p.115-129
• Main Authors: MARK, JOACHIM, DAHLENFORS, RIGMOR, EKEDAHL, CLAES
• Format: Article
• Language: English
• Subjects: Adenoma, Pleomorphic - genetics; Adult; Aged; Aneuploidy; Biological and medical sciences; Chromosome Banding; Chromosomes, Human - ultrastructure; Female; Humans; Karyotyping; Male; Medical sciences; Middle Aged; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Salivary Gland Neoplasms - genetics; Translocation, Genetic
• ISSN: 0018-0661; 1601-5223
• DOI: 10.1111/j.1601-5223.1983.tb00736.x

By means of banding techniques the chromosomes were studied in 61 cultured pleomorphic adenomas. Most of the 34 adenomas with a normal stemline contained variant cells. Those with trisomy 8 or loss of an X chromosome had progressional importance, as also those variant cells containing markers composed of certain specific chromosome segments. In 27 adenomas a total of 30 abnormal stemlines were seen. Of these, 25 had one or two of the following deviations: (1) An anomaly involving No. 8, usually a translocation or deletion of segments distal to 8ql2; in some cases instead either short‐arm translocations‐deletions or trisomy 8. (2) A long‐arm anomaly of No. 12, usually a translocation of segments distal to 12ql3‐15; in rare cases instead a deletion of 12ql3‐ql5. (3) A short‐ or long‐arm anomaly of No. 3, usually translocations of segments distal to 3p21 and 3q21‐25, respectively. In the 5 remaining stemlines related deviations could always be found in a few other abnormal stem‐sidelines, or in variant cells in cases with a normal stemline. The highly specific deviations in abnormal stemlines could be interpreted as illustrating activation of oncogenes and changes of gene dosage.