Loading…
Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA
A kinetic study was made of the ligand exchange reaction between [ 99 m Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[ 99 m Tc]EDTA and [ 99 m Tc]DMSA—ha...
Saved in:
| Published in: | The International journal of applied radiation and isotopes 1983-11, Vol.34 (11), p.1505-1508 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53 |
| container_end_page | 1508 |
| container_issue | 11 |
| container_start_page | 1505 |
| container_title | The International journal of applied radiation and isotopes |
| container_volume | 34 |
| creator | Garcia Muñoz, Mc Garcia Domenech, R. Galvez Alvarez, J. Moreno Frigols, JL |
| description | A kinetic study was made of the ligand exchange reaction between [
99
m
Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[
99
m
Tc]EDTA and [
99
m
Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry. |
| doi_str_mv | 10.1016/0020-708X(83)90284-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80769875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0020708X83902843</els_id><sourcerecordid>80769875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53</originalsourceid><addsrcrecordid>eNp9kE2LFDEQhnNQ1nX1HyjkIKKH1qTTnU48CMPu-gErHmYEYRlCTVK9E-nujEla3X9vxhnm6Cmk6nlfioeQZ5y94YzLt4zVrOqY-v5Kidea1aqpxANyfho_Io9T-lG-tZbqjJxJwdtW63MyLzNs_ODzPQ09zVukEZwPuy3EESzO2VsY6C297UMc5wFoGH3O6Nbrqy_LxTu6zLM7RQd_B5Oj-MduYborVQg2-zDR3z5vS4nWK7u-vlotnpCHPQwJnx7fC_Ltw_Xq8lN18_Xj58vFTWUF47my3FmtNdad0rJvZcO1a1WZKqcQWtlLRCmsbOuad5KzvgEmN5sGLQC00IoL8vLQu4vh54wpm9Eni8MAE4Y5GcU6qVW3B5sDaGNIKWJvdtGPEO8NZ2Zv2OxVmr1Ko4T5Z9iIEnt-7J83I7pT6Ki37F8c95CKxz7CZH06YVpozbquYO8PGBYXvzxGk6zHyaLzEW02Lvj_3_EXn1GZ7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80769875</pqid></control><display><type>article</type><title>Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA</title><source>Backfile Package - Physics General (Legacy) [YPA]</source><creator>Garcia Muñoz, Mc ; Garcia Domenech, R. ; Galvez Alvarez, J. ; Moreno Frigols, JL</creator><creatorcontrib>Garcia Muñoz, Mc ; Garcia Domenech, R. ; Galvez Alvarez, J. ; Moreno Frigols, JL</creatorcontrib><description>A kinetic study was made of the ligand exchange reaction between [
99
m
Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[
99
m
Tc]EDTA and [
99
m
Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.</description><identifier>ISSN: 0020-708X</identifier><identifier>DOI: 10.1016/0020-708X(83)90284-3</identifier><identifier>PMID: 6315599</identifier><identifier>CODEN: ARISEF</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Chemistry ; Drug Stability ; Edetic Acid ; Exact sciences and technology ; Hydrogen-Ion Concentration ; Inorganic chemistry and origins of life ; Kinetics and mechanism of reactions ; Ligands ; Organotechnetium Compounds ; Succimer ; Sulfhydryl Compounds ; Technetium ; Technetium Tc 99m Dimercaptosuccinic Acid ; Temperature</subject><ispartof>The International journal of applied radiation and isotopes, 1983-11, Vol.34 (11), p.1505-1508</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53</citedby><cites>FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0020708X83902843$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3632,27924,27925,46012</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9399077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6315599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia Muñoz, Mc</creatorcontrib><creatorcontrib>Garcia Domenech, R.</creatorcontrib><creatorcontrib>Galvez Alvarez, J.</creatorcontrib><creatorcontrib>Moreno Frigols, JL</creatorcontrib><title>Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA</title><title>The International journal of applied radiation and isotopes</title><addtitle>Int J Appl Radiat Isot</addtitle><description>A kinetic study was made of the ligand exchange reaction between [
99
m
Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[
99
m
Tc]EDTA and [
99
m
Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.</description><subject>Chemistry</subject><subject>Drug Stability</subject><subject>Edetic Acid</subject><subject>Exact sciences and technology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Inorganic chemistry and origins of life</subject><subject>Kinetics and mechanism of reactions</subject><subject>Ligands</subject><subject>Organotechnetium Compounds</subject><subject>Succimer</subject><subject>Sulfhydryl Compounds</subject><subject>Technetium</subject><subject>Technetium Tc 99m Dimercaptosuccinic Acid</subject><subject>Temperature</subject><issn>0020-708X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNp9kE2LFDEQhnNQ1nX1HyjkIKKH1qTTnU48CMPu-gErHmYEYRlCTVK9E-nujEla3X9vxhnm6Cmk6nlfioeQZ5y94YzLt4zVrOqY-v5Kidea1aqpxANyfho_Io9T-lG-tZbqjJxJwdtW63MyLzNs_ODzPQ09zVukEZwPuy3EESzO2VsY6C297UMc5wFoGH3O6Nbrqy_LxTu6zLM7RQd_B5Oj-MduYborVQg2-zDR3z5vS4nWK7u-vlotnpCHPQwJnx7fC_Ltw_Xq8lN18_Xj58vFTWUF47my3FmtNdad0rJvZcO1a1WZKqcQWtlLRCmsbOuad5KzvgEmN5sGLQC00IoL8vLQu4vh54wpm9Eni8MAE4Y5GcU6qVW3B5sDaGNIKWJvdtGPEO8NZ2Zv2OxVmr1Ko4T5Z9iIEnt-7J83I7pT6Ki37F8c95CKxz7CZH06YVpozbquYO8PGBYXvzxGk6zHyaLzEW02Lvj_3_EXn1GZ7w</recordid><startdate>198311</startdate><enddate>198311</enddate><creator>Garcia Muñoz, Mc</creator><creator>Garcia Domenech, R.</creator><creator>Galvez Alvarez, J.</creator><creator>Moreno Frigols, JL</creator><general>Elsevier B.V</general><general>Pergamon Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198311</creationdate><title>Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA</title><author>Garcia Muñoz, Mc ; Garcia Domenech, R. ; Galvez Alvarez, J. ; Moreno Frigols, JL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Chemistry</topic><topic>Drug Stability</topic><topic>Edetic Acid</topic><topic>Exact sciences and technology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Inorganic chemistry and origins of life</topic><topic>Kinetics and mechanism of reactions</topic><topic>Ligands</topic><topic>Organotechnetium Compounds</topic><topic>Succimer</topic><topic>Sulfhydryl Compounds</topic><topic>Technetium</topic><topic>Technetium Tc 99m Dimercaptosuccinic Acid</topic><topic>Temperature</topic><toplevel>online_resources</toplevel><creatorcontrib>Garcia Muñoz, Mc</creatorcontrib><creatorcontrib>Garcia Domenech, R.</creatorcontrib><creatorcontrib>Galvez Alvarez, J.</creatorcontrib><creatorcontrib>Moreno Frigols, JL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia Muñoz, Mc</au><au>Garcia Domenech, R.</au><au>Galvez Alvarez, J.</au><au>Moreno Frigols, JL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA</atitle><jtitle>The International journal of applied radiation and isotopes</jtitle><addtitle>Int J Appl Radiat Isot</addtitle><date>1983-11</date><risdate>1983</risdate><volume>34</volume><issue>11</issue><spage>1505</spage><epage>1508</epage><pages>1505-1508</pages><issn>0020-708X</issn><coden>ARISEF</coden><abstract>A kinetic study was made of the ligand exchange reaction between [
99
m
Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[
99
m
Tc]EDTA and [
99
m
Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6315599</pmid><doi>10.1016/0020-708X(83)90284-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-708X |
| ispartof | The International journal of applied radiation and isotopes, 1983-11, Vol.34 (11), p.1505-1508 |
| issn | 0020-708X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80769875 |
| source | Backfile Package - Physics General (Legacy) [YPA] |
| subjects | Chemistry Drug Stability Edetic Acid Exact sciences and technology Hydrogen-Ion Concentration Inorganic chemistry and origins of life Kinetics and mechanism of reactions Ligands Organotechnetium Compounds Succimer Sulfhydryl Compounds Technetium Technetium Tc 99m Dimercaptosuccinic Acid Temperature |
| title | Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T22%3A26%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stability%20of%20the%20radiopharmaceutical%20%5B%20%5Bformula%20omitted%5D%5DDMSA:%20Study%20of%20the%20ligand%20exchange%20reaction%20with%20%5B%2099Tc%5DEDTA&rft.jtitle=The%20International%20journal%20of%20applied%20radiation%20and%20isotopes&rft.au=Garcia%20Mu%C3%B1oz,%20Mc&rft.date=1983-11&rft.volume=34&rft.issue=11&rft.spage=1505&rft.epage=1508&rft.pages=1505-1508&rft.issn=0020-708X&rft.coden=ARISEF&rft_id=info:doi/10.1016/0020-708X(83)90284-3&rft_dat=%3Cproquest_cross%3E80769875%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c301t-c1dc999e27896f56419d58c1d8d8ea56f6ee63c652217610f4a06bb4ecaaa5a53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=80769875&rft_id=info:pmid/6315599&rfr_iscdi=true |