Effect of Nutrient Depletion on the Sensitivity of Pseudomonas cepacia to Antimicrobial Agents

Pseudomonas cepacia depleted of various nutrients showed marked variation in sensitivity to cetrimide, chlorhexidine, and benzal-konium chloride. In all cases cells depleted of magnesium were the most resistant. It is proposed that these observations may be due to alterations of the envelope of P. c...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1983-11, Vol.72 (11), p.1363-1365
Main Authors: Cozens, R.M., Brown, M.R.W.
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial agents-effect of nutrient depletion on sensitivity of Pseudomonas cepacia
Antiseptics
Benzalkonium Compounds - pharmacology
Biological and medical sciences
Cetrimonium
Cetrimonium Compounds - pharmacology
Chlorhexidine - pharmacology
Culture Media
Drug Resistance, Microbial
Medical sciences
Microbial Sensitivity Tests
Nutrient depletion-effect of sensitivity of Pseudomonas cepacia to antimicrobial agents
Nutrient depletion—effect of senstivity of Pseudomonas cepacia to antimicrobial agents
Pharmacology. Drug treatments
Pseudomonas - drug effects
Pseudomonas cepacia
Pseudomonas cepacia-effect of nutrient depletion on sensitivity to antimicrobial agents
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Summary:Pseudomonas cepacia depleted of various nutrients showed marked variation in sensitivity to cetrimide, chlorhexidine, and benzal-konium chloride. In all cases cells depleted of magnesium were the most resistant. It is proposed that these observations may be due to alterations of the envelope of P. cepacia in response to changes in the growth environment. This may have profound implications for investigations of the resistance of this organism both in vivo and in vitro.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600721135