Retrograde Gap in Fast Pathway Conduction Accentuated by the Class I Antiarrhythmic Agent, Flecainide

A case is reported of a patient with functional duality of AV nodal conduction in whom, during ventricular extrasfimulus testing, there was a gap in retrograde fast pathway conduction which allowed the temporary expression of retrograde slow pathway conduction. The administration of the antiarrhythm...

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Bibliographic Details
Published in:Pacing and clinical electrophysiology 1983-09, Vol.6 (6), p.1273-1277
Main Authors: BEXTON, RODNEY S., HELLESTRAND, KEVIN J., NATHAN, ANTHONY W., BANIM, SEAMUS O., CAMM, A. JOHN
Format: Article
Language:English
Subjects:
Adult
anterograde conduction gaps
Anti-Arrhythmia Agents - pharmacology
Atrioventricular Node - drug effects
Atrioventricular Node - physiopathology
Bundle of His - drug effects
Bundle of His - physiopathology
Cardiac Pacing, Artificial - methods
Electrophysiology
Flecainide
functional duality of AV nodal conduction
Heart Conduction System - drug effects
Heart Conduction System - physiopathology
Humans
Male
Piperidines - pharmacology
Purkinje Fibers - drug effects
Purkinje Fibers - physiopathology
retrograde conduction gaps
Tachycardia - physiopathology
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Summary:A case is reported of a patient with functional duality of AV nodal conduction in whom, during ventricular extrasfimulus testing, there was a gap in retrograde fast pathway conduction which allowed the temporary expression of retrograde slow pathway conduction. The administration of the antiarrhythmic agent flecainide, which has disparate effects on retrograde fast and slow pathway conduction characteristics, accentuated this phenomenon. The electrophysioJogical basis of gap phenomena is discussed.
ISSN:0147-8389
1540-8159
DOI:10.1111/j.1540-8159.1983.tb04470.x