Treponemicidal Levels of Amoxicillin in Cerebrospinal Fluid After Oral Administration

Seven patients in various stages of syphilis were treated by oral administration of amoxicillin (6 g daily) and probenecid (2 g daily) for 15 days. The treponemicidal level of amoxicillin was studied by a Treponema pallidum immobilization assay and found to be 0.070 µg/ml, as compared with 0.003 µg...

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Bibliographic Details
Published in:Sexually transmitted diseases 1983-07, Vol.10 (3), p.148-150
Main Authors: FABER, WILLIAM R., BOS, JAN D., RIETRA, PETER J. G. M., FASS, HANNA, VAN EIJK, RON V. W.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Amoxicillin - administration & dosage
Amoxicillin - metabolism
Amoxicillin - pharmacology
Amoxicillin - therapeutic use
Cerebrospinal Fluid - metabolism
Female
Humans
Male
Middle Aged
Syphilis - drug therapy
Treponema Immobilization Test
Treponema pallidum - drug effects
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Summary:Seven patients in various stages of syphilis were treated by oral administration of amoxicillin (6 g daily) and probenecid (2 g daily) for 15 days. The treponemicidal level of amoxicillin was studied by a Treponema pallidum immobilization assay and found to be 0.070 µg/ml, as compared with 0.003 µg of penicillin/ml. Taking into account the WHO-recommended level of 0.018 µg/ml of penicillin, the minimal level of amoxicillin was estimated as 0.42 µg/ml. This level was obtained in serum and cerebrospinal fluid (CSF) of all patients treated with the above mentioned oral combination. It is concluded that treponemicidal levels of amoxicillin can be obtained in CSF after oral administration. The amoxicillin regimen described may be a valuable alternative to single-dose parenteral penicillin in the treatment of syphilitic patients with suspected CNS involvement, provided that reasonable compliance can be obtained.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-198307000-00011