Halothane stimulates the aggregation of platelets of both normal individuals and those susceptible to malignant hyperthermia

Platelet responses to halothane in normal individuals and in patients susceptible to malignant hyperthermia were evaluated. Platelets in platelet-rich plasma from both normal controls and patients underwent aggregation in response to halothane. There was no significant difference in the degree of ag...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1983-12, Vol.55 (12), p.1249-1257
Main Authors: GERRARD, J. M, DUNCAN, P. G, KOSHYK, S. A, GLOVER, S. M, MCCREA, J. M
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - pharmacology
Adolescent
Adult
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Platelets - drug effects
Blood Platelets - ultrastructure
Blood Proteins - metabolism
Disease Susceptibility
Female
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Halothane - pharmacology
Humans
Male
Malignant Hyperthermia - blood
Medical sciences
Microscopy, Electron
Middle Aged
Phosphorylation
Platelet Aggregation - drug effects
Time Factors
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Summary:Platelet responses to halothane in normal individuals and in patients susceptible to malignant hyperthermia were evaluated. Platelets in platelet-rich plasma from both normal controls and patients underwent aggregation in response to halothane. There was no significant difference in the degree of aggregation between normal subjects and patients. Aggregation by halothane was associated with a change in platelet shape, centralization of platelet granules, and phosphorylation of platelet actin binding protein, myosin light chain, and a 40 000-dalton protein. Aggregation induced by halothane could be inhibited by EGTA, PGE1, adenosine and verapamil, but not by aspirin. Aggregation induced by halothane could be potentiated by small doses of adrenaline or ADP and in some individuals by caffeine. However, previous exposure of platelets to halothane made them subsequently less aggregable to ADP. The results of these studies do not support a use of halothane-induced aggregation of platelets to detect an abnormality in individuals susceptible to malignant hyperthermia, but do provide new evidence of the effects of halothane on cellular function.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/55.12.1249