Fragile chromosome 16(q22) cause a balanced translocation at the same point

A father with a fragile 16(q22) has a son with a de novo balanced translocation 1;16. Both the fragile site and the break point at chromosome 16 are similar (q22). The question of whether the fragile site can cause a structural chromosome abnormality at the same point is discussed.

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Bibliographic Details
Published in:Human genetics 1983-01, Vol.65 (2), p.211-213
Main Authors: GARCIA-SAGREDO, J. M, SAN ROMAN, C, GALLEGO GOMEZ, M. E, LLEDO, G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Child
Chromosome aberrations
Chromosome Fragile Sites
Chromosome Fragility
Chromosomes, Human, 16-18
Humans
Karyotyping
Male
Medical genetics
Medical sciences
Translocation, Genetic
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Description
Summary:A father with a fragile 16(q22) has a son with a de novo balanced translocation 1;16. Both the fragile site and the break point at chromosome 16 are similar (q22). The question of whether the fragile site can cause a structural chromosome abnormality at the same point is discussed.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00286668