Acquired macrophage resistance to in vitro infection with Leishmania

peritoneal macrophages from Leishmania tropica-infected mice developed decreased ability to be infected by amastigotes in vitro during course of infection, decreased in vitro infection apparently due to decreased ingestion of parasites since attachment of parasites to host cells was unimpaired, defe...

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Bibliographic Details
Published in:The Journal of infectious diseases 1983-12, Vol.148 (6), p.1049-1054
Main Authors: Panosian, C.B, Wyler, D.J
Format: Article
Language:English
Subjects:
Amastigotes
Animals
Ascitic Fluid
Bacteriophages
Biological and medical sciences
cell-mediated immunity
Cells, Cultured
Experimental protozoal diseases and models
Female
Host-Parasite Interactions
Human protozoal diseases
Immunobiology
Infections
Infectious diseases
Latex
Leishmania - physiology
Leishmania tropica
Leishmaniasis
Leishmaniasis - immunology
Leishmaniasis - parasitology
Leshmaniasis
Macrophages
Macrophages - immunology
Macrophages - parasitology
Male
Medical sciences
Mice
Mice, Inbred C57BL
Parasite hosts
Parasites
Parasitic diseases
Peritoneal macrophages
Phagocytosis
Protozoal diseases
Resistance, Host
Tropical medicine
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Description
Summary:peritoneal macrophages from Leishmania tropica-infected mice developed decreased ability to be infected by amastigotes in vitro during course of infection, decreased in vitro infection apparently due to decreased ingestion of parasites since attachment of parasites to host cells was unimpaired, defect in ingestion appeared to be specific and could be reversed, possible mechanisms of this decreased macrophage ingestion discussed
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/148.6.1049