Detection of human T-lymphocyte receptor for sheep erythrocytes in immunoregulatory α-globulin

Immunoregulatory alpha-globulin (IRA) has been shown to suppress T cell-dependent immune responses including inhibition of E-rosette formation between human peripheral lymphocytes and sheep erythrocytes. The human lymphocyte receptors, responsible for the interaction with E, can be obtained in solub...

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Bibliographic Details
Published in:Journal of clinical immunology 1983-10, Vol.3 (4), p.352-358
Main Authors: MUSATI, C. C, DAHER, S, BERND, L. A. G, MENDES, N. F
Format: Article
Language:English
Subjects:
Absorption
alpha -globulins
Alpha-Globulins - analysis
Alpha-Globulins - immunology
Alpha-Globulins - physiology
Analysis of the immune response. Humoral and cellular immunity
Antilymphocyte Serum - immunology
Binding, Competitive
Biological and medical sciences
Cell interactions
Erythrocytes - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immune Tolerance
Immunobiology
immunoregulatory factors
lymphocytes T
man
receptors
Receptors, Antigen, T-Cell - analysis
Receptors, Antigen, T-Cell - immunology
Rosette Formation - methods
sheep red blood cells
T-Lymphocytes - metabolism
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Summary:Immunoregulatory alpha-globulin (IRA) has been shown to suppress T cell-dependent immune responses including inhibition of E-rosette formation between human peripheral lymphocytes and sheep erythrocytes. The human lymphocyte receptors, responsible for the interaction with E, can be obtained in soluble form. Recent papers have indicated that these soluble E-receptors may play a regulatory role in the thymus-dependent immune response. In the present paper a possible relationship between IRA and soluble E-receptors was investigated. Absorption of IRA with sheep erythrocytes removed its inhibitory effect upon both E-rosette formation and lymphocyte response to phytohemagglutinin. In gel diffusion experiments a pattern of total identity was obtained between a component of IRA and soluble E receptors, revealed by an anti-E-receptor-specific antiserum (obtained by immunizing a sheep with autologous erythrocytes sensitized with human soluble E-receptors). These results indicate that IRA preparations contain soluble E-receptors. The possibility that E-receptors may be related, to some extent, to the inhibitory effects of IRA protein deserves further investigation.
ISSN:0271-9142
1573-2592
DOI:10.1007/BF00915796