Effects of manganese ions on thyroid function in rat

Rats were treated with MnSO4, H2O (1 mg/100 g/day, SC) for a period of 5 weeks. Thyroxine (T4) and triiodothyronine (T3) levels were measured in thyroid by radioimmunoassay. T4, T3 and thyroid-stimulating hormone (TSH) levels were also estimated by radioimmunoassay in serum. Manganese treatment prod...

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Bibliographic Details
Published in:Archives of toxicology 1983-11, Vol.54 (3), p.243-246
Main Authors: BUTHIEAU, A.-M, AUTISSIER, N
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Manganese - analysis
Manganese - pharmacology
Medical sciences
Metals and various inorganic compounds
Radioimmunoassay
Rats
Rats, Inbred Strains
Thyroid Gland - analysis
Thyroid Gland - drug effects
Thyroid Hormones - blood
Tissue Distribution
Toxicology
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Summary:Rats were treated with MnSO4, H2O (1 mg/100 g/day, SC) for a period of 5 weeks. Thyroxine (T4) and triiodothyronine (T3) levels were measured in thyroid by radioimmunoassay. T4, T3 and thyroid-stimulating hormone (TSH) levels were also estimated by radioimmunoassay in serum. Manganese treatment produced no change in thyroid T4 and T3 levels but induced a significant decrease in serum T4, T3 and TSH levels. This decrease can be interpreted as the result of a pituitary alteration which appears to be related to the high accumulation of manganese in the pituitary gland.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF01239208