T-2 toxin effect on isolated perfused rat hearts

T-2 toxin is the major lethal component of several Fusarium fungi implicated in the disease of man and animals. We used isolated rats hearts to test the T-2 toxin cardiotoxicity. Electrodynamics and ultrastructural parameters were studied. The main changes consisted of decreased contractility and el...

Full description

Saved in:
Bibliographic Details
Published in:Basic research in cardiology 1983-11, Vol.78 (6), p.623-630
Main Authors: YAROM, R, MORE, R, RAZ, S, SHIMONI, Y, SAREL, O, YAGEN, B
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Electrocardiography
Fundamental and applied biological sciences. Psychology
Fusarium
Heart - drug effects
Heart Conduction System - drug effects
In Vitro Techniques
Male
Microbiology
Mycology
Myocardial Contraction - drug effects
Myocardium - ultrastructure
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Rats
Rats, Inbred Strains
Sesquiterpenes - pharmacology
T-2 Toxin - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:T-2 toxin is the major lethal component of several Fusarium fungi implicated in the disease of man and animals. We used isolated rats hearts to test the T-2 toxin cardiotoxicity. Electrodynamics and ultrastructural parameters were studied. The main changes consisted of decreased contractility and electrocardiographic abnormalities without much effect on heart rate or QRS and QT intervals. Ultrastructurally, swelling of myofibers and their mitochondria occurred and damage to the plasma membrane was seen. It is possible that the T-2 effect is mediated through soluble thiol to cause cytoplasmic calcium decrease and loss of plasma membrane integrity.
ISSN:0300-8428
1435-1803
DOI:10.1007/BF01907209