Cysteine proteinase inhibitors in psoriatic epidermis

Human psoriatic epidermis and scales were demonstrated to contain two antigenically separate cysteine proteinase inhibitors, one acidic with an isoelectric point of 4.7-5.0 (ACPI) and one neutral with an isoelectric point of 6.0-6.5 (NCPI), while normal epidermis contains only ACPI. The total papain...

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Bibliographic Details
Published in:Archives of Dermatological Research 1983-01, Vol.275 (5), p.305-309
Main Authors: HOPSU-HAVU, V. K, JORONEN, I. A, JARVINEN, M, RINNE, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cysteine Proteinase Inhibitors
Dermatology
Epidermis - metabolism
Humans
Immunochemistry
Medical sciences
Protease Inhibitors - immunology
Protease Inhibitors - metabolism
Proteins - immunology
Proteins - metabolism
Psoriasis - metabolism
Psoriasis. Parapsoriasis. Lichen
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Summary:Human psoriatic epidermis and scales were demonstrated to contain two antigenically separate cysteine proteinase inhibitors, one acidic with an isoelectric point of 4.7-5.0 (ACPI) and one neutral with an isoelectric point of 6.0-6.5 (NCPI), while normal epidermis contains only ACPI. The total papain (cysteine proteinase) inhibiting activity of the psoriatic epidermis as calculated per mg protein was higher than that in normal epidermis. Both ACPI and NCPI were localized immunocytochemically, mainly in the highest spinous cell layers with less activity in the parakeratotic cells and lower layers of spinous cells. Basal cells were essentially negative.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00417202