expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma

The Toll-like receptor (TLR) signalling pathway is the first system that defends against Leishmania. After recognising Leishmania as nonself, TLRs trigger NF-κB expression. NF-κB proceeds to the nucleus and promotes the transcription of pro-inflammatory cytokines. TLR9 is thus an important factor in...

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Bibliographic Details
Published in:Parasite immunology 2010-11, Vol.32 (11-12), p.769-772
Main Authors: TUON, F.F, FERNANDES, E.R, PAGLIARI, C, DUARTE, M.I.S, AMATO, V.S
Format: Article
Language:English
Subjects:
American tegumentary leishmaniasis
Dermis - immunology
Dermis - pathology
Epidermis - immunology
Epidermis - pathology
Gene Expression Profiling
Granuloma - parasitology
Granuloma - pathology
Humans
Immunohistochemistry
Leishmania
Leishmania braziliensis
Leishmania braziliensis - immunology
Leishmania braziliensis - pathogenicity
leishmaniasis
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - pathology
Macrophages - immunology
Toll-Like Receptor 9 - biosynthesis
Toll-like receptors
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Summary:The Toll-like receptor (TLR) signalling pathway is the first system that defends against Leishmania. After recognising Leishmania as nonself, TLRs trigger NF-κB expression. NF-κB proceeds to the nucleus and promotes the transcription of pro-inflammatory cytokines. TLR9 is thus an important factor in the induction of an effective immune response against Leishmania. We examined the pattern of TLR9 expression in 12 patients with cutaneous leishmaniasis caused by Leishmania braziliensis detected by polymerase chain reaction. Normal skin was analysed as a negative control. TLR9 expression was examined in the dermis and epidermis by immunohistochemical analysis of paraffin-embedded biopsy tissue. TLR9 expression was primarily observed in the granuloma. The protein was detected in a few cells in the dermis. A lower expression level was detected in the epidermis of patients with leishmaniasis when compared with normal skin. The presence of TLR9 in the skin of patients with cutaneous leishmaniasis is associated with granuloma and expressed by macrophages.
ISSN:0141-9838
1365-3024
DOI:10.1111/j.1365-3024.2010.01243.x